GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2243480 | 1 | rs316331 | chr7:65604622 | CCT6P1 | chr7:65216092-65228661:+ | -0.33 | -4.67 | 4.26E-6 | Diabetic kidney disease |
| BLCA | cis | rs2243480 | 1 | rs316332 | chr7:65604299 | CCT6P1 | chr7:65216092-65228661:+ | 0.33 | 4.66 | 4.41E-6 | Diabetic kidney disease |
| BLCA | cis | rs2243480 | 1 | rs316334 | chr7:65602126 | CCT6P1 | chr7:65216092-65228661:+ | 0.33 | 4.56 | 6.79E-6 | Diabetic kidney disease |
| BLCA | cis | rs7258015 | 1 | rs3176766 | chr19:10449778 | KANK2 | chr19:11274944-11308467:- | 0.17 | 4.19 | 3.4E-5 | Systemic lupus erythematosus or rheumatoid arthritis |
| BLCA | cis | rs3204270 | 1 | rs3204270 | chr17:79682051 | ARL16 | chr17:79648234-79650954:- | -0.76 | -10.24 | 6.52E-22 | Dental caries |
| BLCA | cis | rs4803468 | 1 | rs3213861 | chr19:41919944 | B3GNT8 | chr19:41931265-41934635:- | -0.22 | -4.06 | 5.97E-5 | Height |
| BLCA | cis | rs10461617 | 1 | rs33322 | chr5:56175226 | C5orf35 | chr5:56205103-56213010:+ | 0.75 | 11.44 | 2.76E-26 | Type 2 diabetes |
| BLCA | cis | rs10461617 | 1 | rs33325 | chr5:56142547 | C5orf35 | chr5:56205103-56213010:+ | 0.74 | 11.79 | 1.37E-27 | Type 2 diabetes |
| BLCA | cis | rs10461617 | 1 | rs33326 | chr5:56142601 | C5orf35 | chr5:56205103-56213010:+ | 0.75 | 11.66 | 4.12E-27 | Type 2 diabetes |
| BLCA | cis | rs333960 | 1 | rs333960 | chr1:110439480 | GSTM1 | chr1:110230418-110236366:+ | 0.36 | 4.12 | 4.71E-5 | Obesity-related traits |
| BLCA | cis | rs3796352 | 1 | rs33999310 | chr3:52883332 | TMEM110 | chr3:52867139-52931547:- | 0.41 | 3.95 | 9.47E-5 | Immune reponse to smallpox (secreted IL-2) |
| BLCA | cis | rs2275426 | 1 | rs34102169 | chr1:46424864 | CCDC163P | chr1:45960581-45965646:- | -0.34 | -6.37 | 5.58E-10 | Body mass index |
| BLCA | cis | rs1577917 | 1 | rs34106666 | chr6:86676258 | SNHG5 | chr6:86386726-86388451:- | -0.5 | -8.86 | 2.99E-17 | Response to antipsychotic treatment |
| BLCA | cis | rs7927771 | 1 | rs34128973 | chr11:47851376 | C1QTNF4 | chr11:47611216-47615961:- | -0.3 | -5.6 | 4.09E-8 | Subjective well-being |
| BLCA | cis | rs2243480 | 1 | rs34136756 | chr7:65381256 | CCT6P1 | chr7:65216092-65228661:+ | 0.32 | 4.47 | 1.02E-5 | Diabetic kidney disease |